A while back I wrote about a library called django-flashpolicies for providing a flexible remoting environment. Essentially, it frees up the root of your django project for whatever content you like while providing a crossdomain policy file there for remoting applications.
That is still one way to go, but as an advance on that, have a look at the Django-amf-gateway library.
The PyAMF team offers info on it as a way to structure a django project such that you can heap on all the apps you want and allow them to share a common http gateway. By simplifying gateway addresses on the server side django-amf-gateway simplifies resource management on the client side.
Works great in applicable cases.